Ibogamine
Ibogamine is an alkaloid found in Tabernanthe iboga.Basic research related to how addiction affects the brain has used this chemical.Ibogamine persistently reduced the self-administration of cocaine and morphine in rats.. The same study found that Ibogamine (40mg/kg) and Coronaridine (40mg/kg) did not produce “any tremor effects in rats that differ significantly from saline control”. While the related alkaloids Ibogaine(20-40 mg/kg), harmaline (10-40 mg/kg) and desethylcoronaridine (10-40 mg/kg) were “obviously tremorgenic”.
See also
References
- ^ Bartlett, M. F.; Dickel, D. F.; Taylor, W. I. (1958). “The Alkaloids of Tabernanthe iboga. Part IV.1 The Structures of Ibogamine, Ibogaine, Tabernanthine and Voacangine – Journal of the American Chemical Society (ACS Publications)”. Journal of the American Chemical Society. 80 (1): 126–136. doi:10.1021/ja01534a036.
- ^ Kuehne, Martin E.; Reider, Paul J. (1985). “A synthesis of ibogamine – The Journal of Organic Chemistry (ACS Publications)”. The Journal of Organic Chemistry. 50 (9): 1464–1467. doi:10.1021/jo00209a020.
- ^ Levi MS, Borne RF (October 2002). “A review of chemical agents in the pharmacotherapy of addiction”. Curr. Med. Chem. 9 (20): 1807–18. doi:10.2174/0929867023368980. PMID 12369879.
- ^ Jump up to:a b Glick SD, Kuehne ME, Raucci J, Wilson TE, Larson D, Keller RW Jr, Carlson JN (September 1994). “Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum”. Brain Res. 657 (1–2): 14–22. doi:10.1016/0006-8993(94)90948-2. PMID 7820611.
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| Formula | C19H24N2 |
| Molar mass | 280.41 g/mol g·mol−1 |
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