Ibogaine Binding profile

Ibogaine Binding profile

Ibogaine has affinity (K_i) for the following sites in decreasing order of potency: σ₂ (206 nM) > SERT (548.7 nM) > DAT (1,980 nM) > NMDA (2,001 nM) > κ-opioid (2,717 nM) > µ-opioid (4,362 nM) > σ₁ (5,839 nM) > M₃ (12,500 nM) > 5-HT_2A (14,142 nM) > M₁ (22,486 nM) > M₂ (39,409 nM) > D₃ (70,000 nM).^[42] It also has affinity for VMAT and the nACh receptors, among other targets